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Phospho-NF2 (Ser518) Antibody

Phospho-NF2 (Ser518) Antibody

Item no.	CSB-PA149148
Manufacturer	Cusabio
Amount	100 ul
Category	Oncology Neuroscience Molecular Targets for Neuroscience Antibodies By Cell Type Carcinoma Hematology Lymphoma Myeloma Melanoma Sarcoma Mesothelioma Western Blot ELISA Immunofluorescence Primary Antibodies Immunostaining
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ACN antibody,BANF antibody,Bilateral acoustic neuroma antibody,MERL_HUMAN antibody,Merlin antibody,Moesin ezrin radixin like protein antibody,Moesin ezrin radizin like antibody,Moesin-ezrin-radixin-like protein antibody,Neurofibromatosis 2 antibody,Neurofibromatosis type 2 antibody,Neurofibromatosis2 antibody,Neurofibromin 2 antibody,Neurofibromin-2 antibody,Neurofibromin2 antibody,NF 2 antibody,Nf2 antibody,SCH antibody,Schwannomerlin antibody,Schwannomin antibody
Similar products	NF2, SCH, MERL, Schwannomerlin, Neurofibromin 2
Available
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Applications	ELISA, WB, IF; WB:1:500-1:1000, IF:1:100-1:200
Manufacturer - Targets	NF2
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Manufacturer - Alias	ACN antibody, BANF antibody, Bilateral acoustic neuroma antibody, MERL_HUMAN antibody, Merlin antibody, Moesin ezrin radixin like protein antibody, Moesin ezrin radizin like antibody, Moesin-ezrin-radixin-like protein antibody, Neurofibromatosis 2 antibody, Neurofibromatosis type 2 antibody, Neurofibromatosis2 antibody, Neurofibromin 2 antibody, Neurofibromin-2 antibody, Neurofibromin2 antibody, NF 2 antibody, Nf2 antibody, SCH antibody, Schwannomerlin antibody, Schwannomin antibody
Immunogen Species	Human
Immunogen	Peptide sequence around phosphorylation site of serine 518 (R-L-S(p)-M-E) derived from Human Merlin.
Dilution	ELISA:1:2000-1:10000 WB:1:500-1:1000 IF:1:100-1:200
Background	Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Guang-Hui Xiao, et al. (2005) Mol. Cell. Biol , 25: 2384 - 2394. Hi-Su Yang, et al. (2006) Cancer Res , 66: 2708 - 2715. R Bohni, et al. (1994) J. Biol. Chem , 269: 14541 - 14545. Adam J. Ratner, et al. (2001) J. Biol. Chem , 276: 19267 - 19275.
Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
General Research Areas	Neuroscience
Initial Research Areas	Neuroscience
Antigen Species	Human
Antigen	Peptide sequence around phosphorylation site of serine 518 (R-L-S(p)-M-E) derived from Human Merlin.
Clonality	Polyclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 12/18/2025

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