TIMP1 Antibody

Polyclonal Antibody

TIMP1

Clgi antibody, Collagenase inhibitor antibody, Collagenase inhibitor, Human antibody, EPA antibody, EPO antibody, Erythroid Potentiating Activity antibody, Erythroid-potentiating activity antibody, Fibroblast collagenase inhibitor antibody, FLJ90373 antibody, HCI antibody, Human Collagenase Inhibitor antibody, Metalloproteinase inhibitor 1 antibody, Metalloproteinase inhibitor 1 precursor antibody, OTTHUMP00000023214 antibody, TIMP 1 antibody, TIMP antibody, TIMP metallopeptidase inhibitor 1 antibody, TIMP-1 antibody, Timp1 antibody, TIMP1 protein antibody, TIMP1_HUMAN antibody, Tissue Inhibitor of Metalloproteinase 1 antibody, Tissue inhibitor of metalloproteinases 1 antibody, Tissue inhibitor of metalloproteinases antibody, Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor antibody

Synthesized peptide derived from internal of human TIMP1.

Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro, but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.

Anieta M. Sieuwerts, Clin. Chem., May 2007, 10.1373.
KM Fong, Clin. Cancer Res., Aug 1996, 2: 1369.
E. Susol, Rheumatology, Dec 2000, 39: 1332 - 1336.
Christopher J Jackson, Ann Rheum Dis, Mar 1998, 57: 158 - 161.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cardiovascular

Synthesized peptide derived from internal of Human TIMP1.