HDAC1 Antibody

Polyclonal Antibody

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Synthesized peptide derived from human HDAC1.

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer.

Richard L. Cai, J. Biol. Chem., Sep 2000, 275: 27909.
Takayoshi Matsumura, J. Biol. Chem., Apr 2005, 280: 12123 - 12129.
Gregory David, J. Biol. Chem., Jun 2002, 277: 23658 - 23663.
Yuh-Long Chang, PNAS, Aug 2001, 98: 9730.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Epigenetics and Nuclear Signaling

Synthesized peptide derived from Human HDAC1.