FGFR1/FGFR2 (Ab-463) Antibody

Polyclonal Antibody

FGFR1/FGFR2

Basic fibroblast growth factor receptor 1 antibody, bFGF-R-1 antibody, BFGFR antibody, CD331 antibody, CEK antibody, FGFBR antibody, FGFR 1 antibody, FGFR-1 antibody, FGFR1 antibody, FGFR1/PLAG1 fusion antibody, FGFR1_HUMAN antibody, fibroblast growth factor receptor 1 antibody, FLG antibody, FLT-2 antibody, FLT2 antibody, Fms-like gene antibody, Fms-like tyrosine kinase 2 antibody, fms-related tyrosine kinase 2 antibody, HBGFR antibody, heparin-binding growth factor receptor antibody, HH2 antibody, HRTFDS antibody, hydroxyaryl-protein kinase antibody, KAL2 antibody, N-SAM antibody, OGD antibody, Proto-oncogene c-Fgr antibody

Synthesized peptide derived from Internal of human FGFR1/2.

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1, 4, 5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

Itoh N., Biochem. Biophys. Res. Commun. 169:680-685(1990).
Dionne C.A., EMBO J. 9:2685-2692(1990).
Johnson D.E., Mol. Cell. Biol. 10:4728-4736(1990).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cardiovascular

Synthesized peptide derived from Internal of Human FGFR1/2.