USP19 Antibody

Polyclonal Antibody

USP19

8430421I07Rik antibody, AI047774 antibody, Deubiquitinating enzyme 19 antibody, Ubiquitin carboxyl terminal hydrolase 19 antibody, Ubiquitin carboxyl-terminal hydrolase 19 antibody, Ubiquitin specific peptidase 19 antibody, Ubiquitin specific processing protease 19 antibody, Ubiquitin specific protease 19 antibody, Ubiquitin thioesterase 19 antibody, Ubiquitin thiolesterase 19 antibody, Ubiquitin-specific-processing protease 19 antibody, UBP19_HUMAN antibody, Usp19 antibody, Zinc finger MYND domain containing protein 9 antibody, Zinc finger MYND domain-containing protein 9 antibody, ZMYND9 antibody

Synthesized peptide derived from internal of human USP19.

Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non-catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains.

Nagase T., DNA Res. 5:355-364(1998).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cell Biology

Synthesized peptide derived from internal of Human USP19.