ASPSCR1 Antibody

ASPSCR1

Alveolar soft part sarcoma chromosomal region candidate gene 1 protein antibody; Alveolar soft part sarcoma chromosome region candidate 1 (human) antibody; Alveolar soft part sarcoma locus antibody; ASPC antibody; ASPC1_HUMAN antibody; ASPCR 1 antibody; ASPCR1 antibody; ASPL antibody; ASPS antibody; ASPSCR 1 antibody; Aspscr1 antibody; FLJ45380 antibody; RCC 17 antibody; RCC17 antibody; renal cell carcinoma gene on chromosome 17 antibody; renal cell carcinoma papillary 17 antibody; Renal papillary cell carcinoma protein 17 antibody; Tether containing a UBX domain for GLUT4 antibody; Tether containing UBX domain for GLUT4 antibody; TUG antibody; UBX domain containing protein 9 antibody; UBX domain protein 9 antibody; UBX domain-containing protein 9 antibody; UBXD 9 antibody; UBXD9 antibody; UBXN 9 antibody; UBXN9 antibody

Peptide sequence around aa.303 ca.307(P-Q-Q-E-Q) derived from Human ASPSCR1.

Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.

Ladanyi, M. et al. (2001) Oncogene 20, 48-57.
Bogan, J.S. et al. (2003) Nature 425, 727-33.
Yu, C. et al. (2007) J Biol Chem 282, 7710-22.

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugateds. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Signal Transduction

Peptide sequence around aa.303 ~307(P-Q-Q-E-Q) derived from Human ASPSCR1.