DCX Antibody

DCX

DBCN antibody; Dbct antibody; DC antibody; DCX antibody; DCX_HUMAN antibody; Doublecortex antibody; Doublin antibody; FLJ51296 antibody; Lis X antibody; Lis-X antibody; Lissencephalin X antibody; Lissencephalin-X antibody; Lissencephaly X linked antibody; Lissencephaly X linked doublecortin antibody; LISX antibody; Neuronal migration protein doublecortin antibody; OTTHUMP00000023859 antibody; OTTHUMP00000023860 antibody; OTTHUMP00000216315 antibody; OTTHUMP00000216316 antibody; SCLH antibody; XLIS antibody

Peptide sequence around aa.413ca.417( P-T-S-P-G) derived from Human Doublecortin.

Seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of an overlapping, but distinct, signaling pathways that promote neuronal migration.

Des Portes V., Pinard J.-M., Billuart P. Chelly J.Cell 92:51-61(1998)
Pilz D.T., Matsumoto N., Minnerath S.R., Mills P. Hum. Mol. Genet. 7:2029-2037(1998)

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugateds. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Neuroscience

Peptide sequence around aa.413~417( P-T-S-P-G) derived from Human Doublecortin.