CDH23 Antibody

ELISA, IF; IF:1:100-1:500

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Synthesized peptide derived from internal of human CDH23.

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.

Bolz H., Nat. Genet. 27:108-112(2001).
Clark H.F., Genome Res. 13:2265-2270(2003).
Bork J.M., Am. J. Hum. Genet. 68:26-37(2001).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Signal Transduction

Synthesized peptide derived from internal of Human CDH23.