NRG1 Antibody

ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Synthesized peptide derived from human NRG1 isoform-10.

The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Xiao-Feng Le, Cancer Res., Jul 2000, 60: 3522 - 3531.
Samuel D. H. Chan, J. Biol. Chem., Sep 1995, 270: 22608.
Daniel C. Gamett, J. Biol. Chem., Aug 1995, 270: 19022.
Mohammed Rahmatullah, Mol. Cell. Biol., Nov 1998, 18: 6245 - 6252.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Neuroscience

Synthesized peptide derived from Human NRG1 isoform-10.