UBE2T Antibody

Polyclonal Antibody

UBE2T

Cell proliferation inducing gene 50 protein antibody, Cell proliferation-inducing gene 50 protein antibody, HSPC150 antibody, HSPC150 protein similar to ubiquitin conjugating enzyme antibody, PIG50 antibody, Ube2t antibody, UBE2T_HUMAN antibody, Ubiquitin carrier protein T antibody, Ubiquitin conjugating enzyme antibody, ubiquitin conjugating enzyme E2 T antibody, Ubiquitin conjugating enzyme E2T antibody, Ubiquitin protein ligase T antibody, Ubiquitin-conjugating enzyme E2 T antibody, Ubiquitin-protein ligase T antibody

Synthesized peptide derived from internal of human UBE2T.

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.

Okaze H., Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
Hu R.-M., Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
Zhang Q.-H., Genome Res. 10:1546-1560(2000).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cell Biology

Synthesized peptide derived from internal of Human UBE2T.