Phospho-STK4 (Thr183) Antibody

STK4

Kinase responsive to stress antibody; Krs2 antibody; Mammalian STE20 like protein kinase 1 antibody; Mammalian STE20-like protein kinase 1 antibody; Mammalian sterile 20 like 1 antibody; MST-1 antibody; MST1 antibody; Serine/threonine kinase 4 antibody; Serine/threonine protein kinase Krs 2 antibody; Serine/threonine-protein kinase 4 antibody; Serine/threonine-protein kinase Krs-2 antibody; STE20 like kinase MST1 antibody; STE20-like kinase MST1 antibody; STK4 antibody; STK4_HUMAN antibody; TIIAC antibody; YSK3 antibody

Peptide sequence around phosphorylation site of threonine 183 (R-N-T(p)-V-I) derived from Human Mst1/2.

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation By similarity.

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugateds. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Signal Transduction

Peptide sequence around phosphorylation site of threonine 183 (R-N-T(p)-V-I) derived from Human Mst1/2.