EPHA2/EPHA3/EPHA4 (Ab-588/596) Antibody

Polyclonal Antibody

EPHA2/EPHA3/EPHA4

ARCC2 antibody, AW545284 antibody, CTPA antibody, CTPP1 antibody, CTRCT6 antibody, EC 2.7.10.1 antibody, Eck antibody, Eph receptor A2 antibody, EPHA2 antibody, EPHA2_HUMAN antibody, Ephrin receptor antibody, Ephrin receptor EphA2 antibody, Ephrin type A receptor 2 antibody, Ephrin type-A receptor 2 antibody, Epithelial cell kinase antibody, Epithelial cell receptor protein tyrosine kinase antibody, Myk 2 antibody, Myk2 antibody, Sek 2 antibody, Sek2 antibody, Soluble EPHA2 variant 1 antibody, Tyrosine protein kinase receptor ECK antibody, Tyrosine-protein kinase receptor ECK antibody, Tyrosine-protein kinase receptor MPK-5 antibody, Tyrosine-protein kinase receptor SEK-2 antibody

Synthesized non-phosphopeptide derived from human EPHA2/3/4 around the phosphorylation site of tyrosine 588/596 (T-Y(p)-V-D-P).

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Blandine de Saint-Vis, Blood, Dec 2003, 102: 4431 - 4440.
Mirella Dottori, Blood, Oct 1999, 94: 2477 - 2486.
Maria J. Donoghue, J. Neurosci., Jul 1999, 19: 5967.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cardiovascular

Synthesized non-phosphopeptide derived from Human EPHA2/3/4 around the phosphorylation site of tyrosine 588/596 (T-Y(p)-V-D-P).