Phospho-LCK (Tyr505) Antibody

LCK

IMD22 antibody; LCK antibody; Lck p56 antibody; LCK proto-oncogene; Src family tyrosine kinase antibody; LCK_HUMAN antibody; Leukocyte C-terminal Src kinase antibody; LSK antibody; Lymphocyte cell specific protein tyrosine kinase antibody; Lymphocyte cell-specific protein-tyrosine kinase antibody; Lymphocyte specific protein tyrosine kinase antibody; Membrane associated protein tyrosine kinase antibody; Oncogene lck antibody; P56 LCK antibody; p56(LSTRA) protein tyrosine kinase antibody; p56-LCK antibody; p56lck antibody; pp58 lck antibody; pp58lck antibody; Protein YT16 antibody; Proto oncogene tyrosine protein kinase LCK antibody; Proto-oncogene Lck antibody; Protooncogene tyrosine protein kinase LCK antibody; T cell specific protein tyrosine kinase antibody; T cell-specific protein-tyrosine kinase antibody; T lymphocyte specific protein tyrosine kinase p56lck antibody; Tyrosine-protein kinase Lck antibody; YT 16 antibody; YT16 antibody

Peptide sequence around phosphorylation site of tyrosine 505 (G-Q-Y(p)-Q-P) derived from Human Lck.

Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature a beta TCR.

Heck E, et al. (2006) J Virol. Oct, 80(20): 9934-9942
Michie AM, et al. (2000) Mol Biol Cell. May, 11(5): 1585-1595

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugateds. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunology

Peptide sequence around phosphorylation site of tyrosine 505 (G-Q-Y(p)-Q-P) derived from Human Lck.