Phospho-EPHA2/EPHA3/EPHA4 (Tyr588/596) Antibody

Polyclonal Antibody

EPHA2/EPHA3/EPHA4

ARCC2 antibody, AW545284 antibody, CTPA antibody, CTPP1 antibody, CTRCT6 antibody, EC 2.7.10.1 antibody, Eck antibody, Eph receptor A2 antibody, EPHA2 antibody, EPHA2_HUMAN antibody, Ephrin receptor antibody, Ephrin receptor EphA2 antibody, Ephrin type A receptor 2 antibody, Ephrin type-A receptor 2 antibody, Epithelial cell kinase antibody, Epithelial cell receptor protein tyrosine kinase antibody, Myk 2 antibody, Myk2 antibody, Sek 2 antibody, Sek2 antibody, Soluble EPHA2 variant 1 antibody, Tyrosine protein kinase receptor ECK antibody, Tyrosine-protein kinase receptor ECK antibody, Tyrosine-protein kinase receptor MPK-5 antibody, Tyrosine-protein kinase receptor SEK-2 antibody

Peptide sequence around phosphorylation site of tyrosine 588/596 (K-T-Y(p)-V-R)/(R-T-Y(p)-V-D) derived from Human EPHA2/3/4.

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway.

Lindberg R.A., Mol. Cell. Biol. 10:6316-6324(1990).
Zhang Y., Mol. Cell. Proteomics 4:1240-1250(2005).
Zhuang G., J. Biol. Chem. 282:2683-2694(2007)

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Cardiovascular

Peptide sequence around phosphorylation site of tyrosine 588/596 (K-T-Y(p)-V-R)/(R-T-Y(p)-V-D) derived from Human EPHA2/3/4.