KRT17 Antibody

Polyclonal Antibody

KRT17

39.1 antibody, CK 17 antibody, CK-17 antibody, Cytokeratin-17 antibody, K17 antibody, K1C17_HUMAN antibody, Keratin 17 antibody, keratin 17 epitope S1 antibody, keratin 17 epitope S2 antibody, keratin 17 epitope S4 antibody, Keratin 17, type I antibody, Keratin antibody, Keratin type I cytoskeletal 17 antibody, keratin, type i cytoskeletal 17 [version 1] antibody, Keratin-17 antibody, KRT17 antibody, PC antibody, PC2 antibody, PCHC1 antibody, type I cytoskeletal 17 antibody

Synthesized peptide derived from human keratin 17.

May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair By similarity.

M Rosenberg, Mol. Cell. Biol., Feb 1988, 8: 722 - 736.
SM Troyanovsky, J. Cell Sci., Jul 1989, 93: 419.
Kevin M. McGowan, Genes & Dev., Jun 2002, 16: 1412.
Nicholas Bianchi, Mol. Cell. Biol., Aug 2005, 25: 7249 - 7259."

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Signal Transduction

Synthesized peptide derived from Human keratin 17.