MRC2 Antibody

Polyclonal Antibody

MRC2

C-type lectin domain family 13 member E antibody, C-type mannose receptor 2 antibody, CD 280 antibody, CD280 antibody, CD280 antigen antibody, CLEC 13E antibody, CLEC13E antibody, ENDO 180 antibody, ENDO180 antibody, Endocytic receptor (macrophage mannose receptor family) antibody, Endocytic receptor 180 antibody, FLJ35911 antibody, KIAA0709 antibody, Macrophage mannose receptor 2 antibody, Mannose receptor C type 2 antibody, MRC 2 antibody, MRC2 antibody, MRC2_HUMAN antibody, UPAR-associated protein antibody, UPARAP antibody, Urokinase plasminogen activator receptor associated protein antibody, Urokinase receptor associated protein antibody, Urokinase receptor-associated protein antibody, Urokinase-type plasminogen activator receptor-associated protein antibody

Synthesized peptide derived from internal of human MRC2.

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs).

Behrendt N., J. Biol. Chem. 275:1993-2002(2000).
Sheikh H., J. Cell Sci. 113:1021-1032(2000).
Howard M.J., J. Biol. Chem. 277:32320-32331(2002).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cell Biology

Synthesized peptide derived from internal of Human MRC2.