PIAS4 Antibody

PIAS4

E3 SUMO protein ligase PIAS4 antibody; E3 SUMO-protein ligase PIAS4 antibody; FLJ12419 antibody; MGC35296 antibody; PAIASgamma antibody; PIAS 4 antibody; PIAS gamma antibody; PIAS-gamma antibody; Pias4 antibody; PIAS4_HUMAN antibody; PIASG antibody; PIASgamma antibody; PIASy antibody; Protein inhibitor of activated STAT 4 antibody; Protein inhibitor of activated STAT protein 4 antibody; Protein inhibitor of activated STAT protein gamma antibody; Protein inhibitor of activated STAT protein PIASy antibody; Zinc finger MIZ type containing 6 antibody; ZMIZ 6 antibody; ZMIZ6 antibody

Synthesized peptide derived from Internal of human PIAS4.

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

Zendra E. Zehner, AACR Meeting Abstracts, Apr 2005, 2005: 456.
Amador Albor, J. Biol. Chem., Sep 2006, 281: 25850 - 25866.
Christina-Maria Hecker, J. Biol. Chem., Jun 2006, 281: 16117 - 16127.
Yun Zhao, Stem Cells, Apr 2007, 10.1634.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Epigenetics and Nuclear Signaling

Synthesized peptide derived from Internal of Human PIAS4.