CAMKK2 Antibody

Polyclonal Antibody

CAMKK2

Calcium/calmodulin dependent protein kinase beta antibody, Calcium/calmodulin dependent protein kinase kinase 2 antibody, Calcium/calmodulin dependent protein kinase kinase 2 beta antibody, Calcium/calmodulin dependent protein kinase kinase beta antibody, Calcium/calmodulin-dependent protein kinase kinase 2 antibody, Calcium/calmodulin-dependent protein kinase kinase beta antibody, CaM kinase kinase beta antibody, CaM KK beta antibody, CaM-kinase kinase 2 antibody, CaM-kinase kinase beta antibody, CaM-KK 2 antibody, CaM-KK beta antibody, CaMKK 2 antibody, CAMKK antibody, CaMKK beta antibody, CAMKK beta protein antibody, Camkk2 antibody, CAMKKB antibody, KKCC2_HUMAN antibody

Synthesized peptide derived from internal of human CAMKK2.

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals By similarity. Seems to be involved in hippocampal activation of CREB1 By similarity. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.

Hsu L.-S., J. Biol. Chem. 276:31113-31123(2001).
Anderson K.A., J. Biol. Chem. 273:31880-31889(1998).
Ishikawa Y., FEBS Lett. 550:57-63(2003).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Signal Transduction

Synthesized peptide derived from internal of Human CAMKK2.