MNAT1 Antibody

MNAT1

MNAT 1 antibody; CAP35 antibody; CDK activating kinase assembly factor MAT1 antibody; CDK-activating kinase assembly factor MAT1 antibody; CDK7/cyclin H assembly factor antibody; CDK7/cyclin-H assembly factor antibody; Cyclin G1 interacting protein antibody; Cyclin-G1-interacting protein antibody; MAT1 antibody; MAT1_HUMAN antibody; Menage a trois 1 (CAK assembly factor) antibody; Menage a trois antibody; Menage a trois homolog 1; cyclin H assembly factor (Xenopus laevis) antibody; MNAT CDK activating kinase assembly factor 1 antibody; Mnat1 antibody; p35 antibody; p36 antibody; RING finger protein 66 antibody; RING finger protein MAT1 antibody; RNF66 antibody; TFB3 antibody

Synthesized peptide derived from internal of human MAT1.

Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.

Tassan J.-P., EMBO J. 14:5608-5617(1995).
Yee A., Cancer Res. 55:6058-6062(1995).
Tirode F., Mol. Cell 3:87-95(1999).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cell Biology

Synthesized peptide derived from internal of Human MAT1.