DNMT3B Antibody

DNMT3B

Cytosine 5methyltransferase 3B antibody; DNA antibody; DNA (cytosine 5) methyltransferase 3 beta antibody; DNA (cytosine 5)-methyltransferase 3B antibody; DNA (cytosine-5)-methyltransferase 3B antibody; DNA methyltransferase HsaIIIB antibody; DNA MTase HsaIIIB antibody; DNM3B_HUMAN antibody; Dnmt3b antibody; EC 2.1.1.37 antibody; ICF antibody; ICF1 antibody; M.HsaIIIB antibody; MGC124407 antibody; RP23-89H14.3 antibody

Synthesized peptide derived from N-terminal of human DNMT3B.

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing By similarity. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.

Deloukas P., Nature 414:865-871(2001).
Li H., J. Biol. Chem. 281:19489-19500(2006).
Wijmenga C., Hum. Mutat. 16:509-517(2000).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Epigenetics and Nuclear Signaling

Synthesized peptide derived from N-terminal of Human DNMT3B.