UBASH3A Antibody

Polyclonal Antibody

UBASH3A

Cbl interacting protein 4 antibody, Cbl-interacting protein 4 antibody, CLIP4 antibody, STS 2 antibody, STS-2 antibody, Suppressor of T cell receptor signaling 2 antibody, Suppressor of T-cell receptor signaling 2 antibody, T cell ubiquitin ligand antibody, T cell ubiquitin ligand protein antibody, T-cell ubiquitin ligand 1 antibody, TULA antibody, TULA-1 antibody, UBASH3A antibody, ubiquitin associated and SH3 domain containing, A antibody, Ubiquitin-associated and SH3 domain-containing protein A antibody, UBS3A_HUMAN antibody

Synthesized peptide derived from internal of human UBASH3A.

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Wattenhofer M., Hum. Genet. 108:140-147(2001).
Feshchenko E.A., Oncogene 23:4690-4706(2004).
Hattori M., Nature 405:311-319(2000).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cell Biology

Synthesized peptide derived from internal of Human UBASH3A.