STK10 Antibody

Polyclonal Antibody

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Synthesized peptide derived from internal of human STK10.

Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro, however such data require additional evidences in vivo.

Kuramochi S., Immunogenetics 49:369-375(1999).
Ota T., Nat. Genet. 36:40-45(2004).
Schmutz J., Nature 431:268-274(2004).

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Signal Transduction

Synthesized peptide derived from internal of Human STK10.