Phospho-CD22 (Tyr807) Antibody

CD22

B cell receptor CD22 precursor antibody; B lymphocyte cell adhesion molecule antibody; B-cell receptor CD22 antibody; B-lymphocyte cell adhesion molecule antibody; BL CAM antibody; BL-CAM antibody; BLCAM antibody; CD 22 antibody; CD22 antibody; CD22 antigen antibody; CD22 molecule antibody; CD22 protein antibody; CD22_HUMAN antibody; Lectin 2 antibody; Leu14 antibody; Lyb8 antibody; MGC130020 antibody; sialic acid binding Ig like lectin 2 antibody; Sialic acid binding immunoglobulin like lectin 2 antibody; Sialic acid-binding Ig-like lectin 2 antibody; SIGLEC 2 antibody; Siglec-2 antibody; SIGLEC2 antibody; T cell surface antigen Leu 14 antibody; T-cell surface antigen Leu-14 antibody

Peptide sequence around phosphorylation site of tyrosine 807 (G-D-Y(p)-E-N) derived from Human BL-CAM.

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to alpha2, 6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Wilson G.L., J. Exp. Med. 173-137-146(1991).
Wilson G.L., J. Immunol. 150:5013-5024(1993).
Stamenkovic I., Nature 345-74-77(1990).

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugateds. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Immunology

Peptide sequence around phosphorylation site of tyrosine 807 (G-D-Y(p)-E-N) derived from Human BL-CAM.