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E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.Nagase T., DNA Res. 7:65-73(2000).The MGC Project Team, Genome Res. 14:2121-2127(2004).Bartee E., J. Virol. 78:1109-1120(2004).
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