Phospho-NFKBIE (Ser22) Antibody

NFKBIE

I kappa B epsilon antibody; I-kappa-B-epsilon antibody; IkappaBepsilon antibody; IkB E antibody; IkB-E antibody; IkB-epsilon antibody; IKBE antibody; IKBE_HUMAN antibody; MGC72568 antibody; NF kappa B inhibitor epsilon antibody; NF kappa BIE antibody; NF-kappa-B inhibitor epsilon antibody; NF-kappa-BIE antibody; NFkappa BIE antibody; NFkappaB inhibitor epsilon antibody; NFKBIE antibody; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor epsilon antibody; OTTHUMP00000016522 antibody; Slc35b2 antibody; solute carrier family 35; member B2 antibody

Peptide sequence around phosphorylation site of serine 22 (I-E-S(p)-L-R) derived from Human IkB-e.

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes.

Shirane M, et al. (1999) J Biol Chem, 274(40): 28169-74
Karin, M. and Ben-Neriah, Y. (2000) Annu. Rev. Immunol. , 18, 621-663.
Chen, Z.J. et al. (1996) Cell, 84, 853-862.
Brown, K. et al. (1995) Science, 267, 1485-1488.

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugateds. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Signal Transduction

Peptide sequence around phosphorylation site of serine 22 (I-E-S(p)-L-R) derived from Human IkB-e.