BCL2L12 Antibody

Polyclonal Antibody

BCL2L12

B2L12_HUMAN antibody, BCL 2 like 12 (proline rich) antibody, BCL 2 like 12 antibody, BCL 2 like 12 isoform 1 antibody, Bcl 2 like 12 protein antibody, Bcl 2 related proline rich protein antibody, Bcl-2-like protein 12 antibody, Bcl-2-related proline-rich protein antibody, BCL2 like 12 (proline rich) antibody, BCL2 like 12 antibody, BCL2 like 12 isoform 1 antibody, Bcl2 like 12 protein antibody, Bcl2 related proline rich protein antibody, Bcl2-L-12 antibody, BCL2L12 antibody, BPR antibody, MGC120313 antibody, MGC120314 antibody, MGC120315 antibody

Synthesized peptide derived from internal of human BCL2L12.

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants.

Scorilas A., Genomics 72:217-221(2001) [PubMed: 11401436].
Hillman R.T., Genome Biol. 5:R8.1-R8.16(2004) [PubMed: 14759258].
Olsen J.V., Cell 127:635-648(2006) [PubMed: 17081983].

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Cell Biology

Synthesized peptide derived from internal of Human BCL2L12.