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PKM Polyclonal Antibody

PKM Polyclonal Antibody

Item no.	E-AB-40250-120
Manufacturer	Elabscience
Amount	120 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Oncology Metabolism Glucose Homeostasis Assisted reproductive technologies Embryo manipulation Antibodies Western Blot Primary Antibodies By Organ Thyroid Cancer
Type	Antibody Polyclonal
Applications	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CTHBP, Cytosolic thyroid hormone binding protein, Cytosolic thyroid hormone-binding protein, KPYM, MGC3932, OIP 3, OIP-3, OIP3, OPA interacting protein 3, Opa-interacting protein 3, p58, PK muscle type, PK, muscle type, PK2, PK3, PKM, PKM2, pykm, Pyruvate kinase 2/3, Pyruvate kinase 3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle, Pyruvate kinase muscle isozyme, pyruvate kinase PKM, Pyruvate kinase, muscle 2, TCB, THBP1, Thyroid hormone binding protein 1, Thyroid hormone binding protein cytosolic, Thyroid hormone-binding protein 1, Tumor M2 PK, Tumor M2-PK
Similar products	PKM2, PKM, OIP3, PK2, PK3, Pyruvate kinase isozymes M1/M2, Cytosolic thyroid hormone-binding protein, Opa-interacting protein 3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, Tumor M2-PK, p58, muscle type, PK, CTHBP, MGC3932, TCB, THBP1, OIP-3, Cytosolic thyroid hormone binding protein, OIP 3, OPA interacting protein 3, Pyruvate kinase 3, Pyruvate kinase muscle, Thyroid hormone binding protein cytosolic, Pyruvate kinase, Tumor M2 PK, KPYM, PK muscle type, pykm, pyruvate kinase PKM, muscle 2, Thyroid hormone binding protein 1
Shipping Condition	Cool pack
Available
Manufacturer - Category	Polyclonal Antibody
Shipping Temperature	Biological Ice Packs
Storage Conditions	-20°C for 12 months
Calculated Molecular Weight	56, 58 kDa
Observed Molecular Weight	58 kDa
Research Areas	Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction
Background	PKM2, also named as OIP3, PK2, PK3, PKM, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM2 plays a general role in caspase independent cell death of tumor cells. The activity of the M2 isoform (but not the M1 isoform) can be inhibited by tyrosine kinase signalling in tumourcells.The primary pyruvate kinase isoform before tumour development is PK-M1; however, the primary isoform from four independent tumours is PK-M2. PKM2, Pyruvate kinase isozymes M1/M2, has 2 isoforms .The immunogen of this antibody is M2 isoform, also called PKM2.
Concentration	2 mg/mL
Buffer	PBS with 0.05% Proclin300 and 50% glycerol, pH 7.4.
Purification Method	Affinity Purification
Recommended Dilution	WB 1:500-1:1000
Clonality	Polyclonal
Immunogen	Recombinant Human Pyruvate kinase PKM protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.