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ALKBH8 Polyclonal Antibody

ALKBH8 Polyclonal Antibody

Item no.	E-AB-52350-20
Manufacturer	Elabscience
Amount	20 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Metabolism Diabetes Glucose Homeostasis Antibodies Obesity Immunohistochemistry Western Blot ELISA Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	4930562C03Rik, 8030431D03Rik, 9430088N01Rik, ABH8, alkB alkylation repair homolog 8 (E. coli), alkB alkylation repair homolog 8, AlkB homologue 8, ALKB8, ALKBH8, Alkylated DNA repair protein alkB homolog 8, FLJ38204, MGC10235, OTTHUMP00000211286, OTTHUMP00000211287, Probable alpha-ketoglutarate-dependent dioxygenase ABH8, RGD1304687, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
Similar products	ALKBH8, ABH8, FLJ38204, MGC10235, AlkB homologue 8, OTTHUMP00000211286, OTTHUMP00000211287, ALKB8, Alkylated DNA repair protein alkB homolog 8, 4930562C03Rik, 8030431D03Rik, 9430088N01Rik, alkB alkylation repair homolog 8 (E. coli), alkB alkylation repair homolog 8, Probable alpha-ketoglutarate-dependent dioxygenase ABH8, RGD1304687, S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8, tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	ALKBH8
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight	75 kDa
Observed Molecular Weight	Refer to figures
Research Areas	Cancer, Epigenetics and Nuclear Signaling
Background	ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. Three isoforms exist for ALKBH8 due alternative splicing of the gene.
Concentration	0.6 mg/mL
Buffer	PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method	Antigen affinity purification
Recommended Dilution	WB 1:500-1:2000; IHC 1:25-1:100
Abbreviation	ALKBH8
Clonality	Polyclonal
Immunogen	Full length fusion protein
Category ID III	Polyclonal Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.