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NGEF Polyclonal Antibody

NGEF Polyclonal Antibody

Item no.	E-AB-52771-200
Manufacturer	Elabscience
Amount	200 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Neuroscience Neural Signaling Antibodies Cell Biology Cytoskeleton Immunohistochemistry Western Blot ELISA Primary Antibodies small GTPases Rho Subfamily
Type	Antibody Polyclonal
Applications	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ARHGEF27, Eph receptor-interacting exchange protein, Eph-interacting exchange protein, EPHEXIN, Ephexin-1, Guanine nucleotide exchange factor, neuronal, Neuronal guanine nucleotide exchange factor, Ngef, NGEF
Similar products	NGEF, Ngef, neuronal, EPHEXIN, Guanine nucleotide exchange factor, ARHGEF27, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, Ephexin-1, Eph receptor-interacting exchange protein
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	NGEF
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight	82 kDa
Observed Molecular Weight	Refer to figures
Manufacturer - Research Areas	Neuroscience, Signal transduction
Background	Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Concentration	0.6 mg/mL
Buffer	PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method	Antigen affinity purification
Recommended Dilution	WB 1:500-1:2000; IHC 1:30-1:150
Abbreviation	NGEF
Clonality	Polyclonal
Immunogen	Fusion protein of human NGEF
Category ID III	Polyclonal Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.