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XAB2 Polyclonal Antibody

XAB2 Polyclonal Antibody

Item no.	E-AB-53550-200
Manufacturer	Elabscience
Amount	200 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Category	Oncology Metabolism Diabetes Antibodies By Cell Type Immunohistochemistry Western Blot ELISA Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	0610041O14Rik, adapter protein ATH 55, Adapter protein ATH-55, Ath55, AV025587, Crn related protein kim1 , crn-related protein kim1, DKFZp762C1015, HCNP, HCNP protein, HCRN, KIAA1177, NTC90, PP3898, Pre-mRNA-splicing factor SYF1, Protein HCNP, RNA splicing factor, SYF1, SYF1 homolog, SYF1 homolog, RNA splicing factor , SYF1 pre mRNA splicing factor, SYF1, Xab2, XPA binding protein 2, XPA-binding protein 2
Similar products	HCNP, KIAA1177, SYF1, Pre-mRNA-splicing factor SYF1, Protein HCNP, XPA-binding protein 2, Xab2, HCRN, RNA splicing factor, DKFZp762C1015, NTC90, SYF1 homolog, crn-related protein kim1, 0610041O14Rik, adapter protein ATH 55, Adapter protein ATH-55, Ath55, AV025587, Crn related protein kim1, HCNP protein, PP3898, XPA binding protein 2, SYF1 pre mRNA splicing factor
Shipping Condition	Cool pack
Hazard information	Comply with cargo safety certificate
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	XAB2
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight	100 kDa
Observed Molecular Weight	Refer to figures
Manufacturer - Research Areas	Epigenetics and Nuclear Signaling
Background	HCNP, also known as XAB2 (Xeroderma pigmentosum group A (XPA) binding protein 2), HCRN, SYF1 or NTC90, is a nuclear protein that participates in transcription, transcription-coupled repair (TCR) and pre-mRNA splicing. It contains fifteen tetratricopeptide repeat motifs and associates with nucleotide excision repair machinery. More specifically, HCNP associates with Cockayne syndrome group A and B proteins (CSA and CSB), RNA Polymerase II (Pol II) and XPA in response to DNA damage and is believed to function in the TCR pathway. HCNP also functions as an essential component of a pre-mRNA splicing complex of the spliceosome (composed of AQR (aquarius), PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. In addition, HCNP functions as a component of the RAR corepressor complex with RAR and HDAC3 and exhibits an inhibitory effect on ATRA-induced cell differentiation. This suggests that HCNP may function as useful target in cancer therapy.
Concentration	0.4 mg/mL
Buffer	PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Purification Method	Antigen affinity purification
Recommended Dilution	WB 1:500-1:2000; IHC 1:25-1:100
Abbreviation	XAB2
Clonality	Polyclonal
Immunogen	Synthetic peptide of human XAB2
Category ID III	Polyclonal Antibodies

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.