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Purified Anti-Mouse CD103 Antibody[M290]

Purified Anti-Mouse CD103 Antibody[M290]

Item no.	E-AB-F1090A-25
Manufacturer	Elabscience
Amount	25 ug
Quantity options	100 ug 1 mg 25 ug 50 ug 5 mg
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Applications	FC, Blocking
Clone	M290
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2a Kappa
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Integrin alpha-E, Itgae, Integrin alpha M290, CD103,
Shipping Condition	Cool pack
Available
Manufacturer - Category	Flow Cytometry Antibodies
Manufacturer - Isotype	Rat IgG2a, κ
Shipping Temperature	Ice bag
Storage Conditions	Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Background	CD103 is a type I transmembrane glycoprotein known as αE integrin or Integrin αIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-β stimulation. In association with integrin β7, CD103 is expressed as αE/β7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium.
Concentration	≥1 mg/mL
Buffer	Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
Abbreviation	CD103
Clonality	Monoclonal
Usage	Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 10^6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.