APC Anti-Human CD197/CCR7 Antibody[G043H7]

Primary Antibodies

CD197

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Monoclonal

Flow Cytometry Antibodies