Elab Fluor® 647 Anti-Mouse IL-17A Antibody[TC11-18H10.1]

ICFCM

Rat IgG1, κ

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Monoclonal