PE Anti-Human CD279/PD-1 Antibody[EH12.2H7]

Mouse IgG1, κ

This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.

Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.

Monoclonal