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anti- ARHGEF5 antibody

anti- ARHGEF5 antibody

Item no.	FNab00563-100ug
Manufacturer	FineTest
Amount	100ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	liquid
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	TIM
Available
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Clonality	polyclonal
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Guanine nucleotide exchange factor which activates Rho GTPases(PubMed:15601624). Strongly activates RHOA(PubMed:15601624). Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1(By similarity). Involved in regulation of cell shape and actin cytoskeletal organization(PubMed:15601624). Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia(PubMed:14662653). Required for SRC-induced podosome formation(By similarity). Involved in positive regulation of immature dendritic cell migration(By similarity).
Immunogen	Rho guanine nucleotide exchange factor(GEF) 5
Observed MW	60 kDa
Uniprot ID	Q12774
Tested Application	ELISA, WB, IHC, IP
Recommended dilution	WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Gene ID	7984
Research Area	Signal Transduction

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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