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ATF4 antibody

ATF4 antibody

Item no.	FNab00662-100ug
Manufacturer	FineTest
Amount	100 ug
Quantity options	100 ug 100 ug 100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, FC, IP, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4),Activating transcription factor 4,Cyclic AMP-responsive element-binding protein 2 (CREB-2,cAMP-responsive element-binding protein 2),Tax-responsive enhancer element-binding protein 67 (TaxREB67),ATF4,CREB2,TXREB
Available
Manufacturer - Targets	ATF4
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Transcriptional activator. Binds the cAMP response element(CRE)(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production(By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase(ASNS) in response to endoplasmic reticulum(ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements(CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors(PubMed:26086088).
Clonality	polyclonal
Immunogen	activating transcription factor 4(tax-responsive enhancer element B67)
Observed MW	50-58 kDa, 35-38 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:50-1:500
Manufacturer - Research Area	Neuroscience, Epigenetics, Metabolism, Developmental biology
Manufacturer - Synonym	Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4), Activating transcription factor 4, Cyclic AMP-responsive element-binding protein 2 (CREB-2, cAMP-responsive element-binding protein 2), Tax-responsive enhancer element-binding protein 67 (TaxREB67), ATF4, CREB2, TXREB

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