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BHLHE22 antibody

BHLHE22 antibody

Item no.	FNab00887-100ug
Manufacturer	FineTest
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IF, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Class E basic helix-loop-helix protein 22 (bHLHe22),Class B basic helix-loop-helix protein 5 (bHLHb5),Trinucleotide repeat-containing gene 20 protein,BHLHE22,BHLHB5,TNRC20
Available
Manufacturer - Targets	BHLHE22
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Inhibits DNA binding of TCF3/E47 homodimers and TCF3(E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA(By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.
Clonality	polyclonal
Immunogen	basic helix-loop-helix family, member e22
Observed MW	37 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:200-1:1000; IF: 1:10-1:100
Manufacturer - Research Area	Neuroscience, Metabolism, Developmental biology

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