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anti- BHLHE22 antibody

anti- BHLHE22 antibody

Manufacturer	FineTest
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Specific against	Human, Mouse
Isotype	IgG
Format	liquid
Amount	100ug
Host	Rabbit
Item no.	FNab00887-100ug
eClass 6.1	32160702
eClass 9.0	32160702
Available
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Clonality	polyclonal
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Inhibits DNA binding of TCF3/E47 homodimers and TCF3(E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA(By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.
Immunogen	basic helix-loop-helix family, member e22
Observed MW	37 kDa
Uniprot ID	Q8NFJ8
Tested Application	ELISA, WB, IF
Recommended dilution	WB: 1:200-1:1000; IF: 1:10-1:100
Gene ID	27319
Research Area	Neuroscience, Metabolism, Developmental biology

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

available

Delivery expected until 8/2/2023