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TUT4 antibody

TUT4 antibody

Item no.	FNab09609-100ug
Manufacturer	FineTest
Amount	100 ug
Quantity options	100 ug 100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IF, IP, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Terminal uridylyltransferase 4 (TUTase 4),Zinc finger CCHC domain-containing protein 11,TUT4,KIAA0191,ZCCHC11
Available
Manufacturer - Targets	TUT4
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Uridylyltransferase that mediates the terminal uridylation of mRNAs with short(less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay(PubMed:25480299). Involved in microRNA(miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7(pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem(ES) cell pluripotency(By similarity). Does not bind RNA directly, but recruited to RNA targets by RNA-binding protein LIN28A. Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression(By similarity). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.
Clonality	polyclonal
Immunogen	zinc finger, CCHC domain containing 11
Observed MW	185 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:200-1:2000; IP: 1:500-1:5000; IF: 1:20-1:200
Manufacturer - Research Area	Epigenetics

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