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Azide-PEG4-VC-PAB-Doxorubicin

Azide-PEG4-VC-PAB-Doxorubicin

Item no.	HY-136288-10mg
Manufacturer	MedChem Express
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Antibodies Primary Antibodies
Type	Antibody Polyclonal
Specific against	other
Purity	99.62
Citations	[1]Hayward R, et al. Doxorubicin cardiotoxicity in the rat: an in vivo characterization. J Am Assoc Lab Anim Sci. 2007 Jul;46(4):20-32.
Smiles	O[C@@](CC1=C2O)(C[C@@H](C1=C(C(C(C3=C4C=CC=C3OC)=O)=C2C4=O)O)O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC(OCC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)C=C6)=O)C(CO)=O
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Type	ADC Related
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Drug-Linker Conjugates for ADC
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	1222.25
Product Description	Azide-PEG4-VC-PAB-Doxorubicin is a agent-linker conjugate composed of a cytotoxic anthracycline antibiotic Doxorubicin and a linker Azide-PEG4-VC-PAB to make antibody agent conjugate (ADC)[1]. Azide-PEG4-VC-PAB-Doxorubicin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Manufacturer - Research Area	Cancer
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Antibody-drug Conjugate/ADC Related
Clinical information	No Development Reported
Isoform	Daunorubicins/Doxorubicins

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