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Anti-Mouse IL-1R In Vivo Antibody - Low Endotoxin (JAMA-147)

Anti-Mouse IL-1R In Vivo Antibody - Low Endotoxin (JAMA-147)

Manufacturer	IchorBio
Category	Antibodies In Vivo Antibodies Western Blot Blocking
Type	Antibody
Specific against	Mouse
Clone	JAMA-147
Isotype	IgG
Applications	WB, Blocking
Amount	1mg
Host	Hamster - Armenian
Item no.	ICH1117-1MG
Targets	CD121a
eClass 6.1	32160702
eClass 9.0	32160702
Available
Aggregation	Aggregation level <= 5%
Application Notes	Each investigator should determine their own optimal working dilution for specific applications.
Background	IL-1 binds two receptors, IL-1RI and IL-1RII. The ligands IL-1alpha and IL-1beta exert all of their various biological actions by binding IL-1RI. IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1alpha and IL-1beta, thereby reducing their biological effects. Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP. IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. It is an 80 kD transmembrane glycoprotein.
Concentration	1.0 - 5.0 mg/ml
Endotoxin	<= 1.0 EU/mg as determined by the LAL method
Formulation	0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Immunogen	Extracellular domain of mouse IL-1 R type 1
Product Type	Low Endotoxin, anti-mouse
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Storage	anti-IL-1R In Vivo Antibody - Low Endotoxin (JAMA-147) is stable for at least one week when stored sterile at 2-8C. For long term storage aseptically aliquot in working volumes without diluting and store at -20C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1mg

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Delivery expected until 6/6/2024