Anti-Mouse TNF Alpha (TN3-19.12) In Vivo Antibody - Ultra-Low Endotoxin

Ultra-Low Endotoxin, anti-mouse, monoclonal antibody

Blue ice

Aggregation level ≤ 1%

Activated monocytes, neutrophils, macrophages, T cells, B cells, NK cells, LAK cells

The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity. It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites. TNF-alpha is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-alpha secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-alpha has been detected in synovial fluid of patients with rheumatoid arthritis. Clone TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-alpha

≤ 0.5 EU/mg as determined by the LAL method

This monoclonal antibody was purified using Protein A

Recombinant mouse TNFalpha

Anti-TNF alpha In Vivo Antibody - Low Endotoxin [TN3-19.12] (ICH1136)

Armenian Hamster IgG Isotype Control for In Vivo - Ultra Low Endotoxin [PIP] (ICH2251UL)