Bulk Anti-Human CD25 (7G7B6) Antibody

ELISA, Flow Cytometry, Immunofluorescence, Immunoprecipitation, Western Blot

Mouse IgG2a

Blue ice

Aggregation level ≤ 5%

IL-2Rα is expressed on activated mature T and B lymphocytes, during early stages of thymocytes development, pre-B cells, and in activated CD4+ memory T-lymphocytes

CD25 (IL-2Rα) is the 55 kDa subunit of the interleukin 2 receptor alpha chain which has been shown to play roles in lymphocyte differentiation, activation, and proliferation. IL-2Rα is a transmembrane glycoprotein comprised of a heavily glycosylated extracellular domain, a transmembrane region and a short cytoplasmic tail. IL-2Rα heterodimerizes with IL-2Rβ (CD122) and IL-2Rγ (CD132) and forms the IL-2 receptor complex. IL-2Rα by itself binds IL-2 with relatively low affinity, while the IL-2 receptor complex binds IL-2 with high affinity. IL-2Rα mutations cause severe immunodeficiency.

≤ 1.0 EU/mg as determined by the LAL method

This monoclonal antibody was purified using Protein A

Recombinant human peripheral blood mononuclear cells (PBMCs)

ICH3001-100ml; ICH3002-100ml; ICH3003-100ml