Comparison

Bulk Anti-Human CD195 (HEK/1/85a/7a) Antibody (CCR5) European Partner

Item no. ICH1172-5MG
Manufacturer IchorBio
Amount 5 mg
Quantity options 100 mg 25 mg 50 mg 5 mg
Category
Type Antibody
Applications FC, ICC
Clone HEK/1/85a/7a
Specific against Human (Homo sapiens)
Host Rat
Isotype IgG2b Kappa
Purity ≥95% monomer by analytical SEC⋅>95% by SDS Page
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, HIV-1 fusion coreceptor, CD195
Shipping Condition Cool pack
Available
Specificity Clone HEK/1/85a/7a recognizes an epitope on human CCR5
Manufacturer - Applications
Flow Cytometry, ImmunoCytochemistry
Manufacturer - Category
Low Endotoxin, anti-human, monoclonal antibody
Manufacturer - Isotype
Rat IgG2b Kappa
Manufacturer - Targets
CCR5
Shipping Temperature
Blue ice
Storage Conditions
This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Aggregation
Aggregation level ≤ 5%
Formulation
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Antigen Distribution
CCR5 is expressed on memory T cells, macrophages, and immature dendritic cells (DCs)
Application Notes
The suggested concentration for this CD195 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 10^6 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application.
Background
CCR5 antibody, HEK/1/85a/7a, recognizes C-C chemokine receptor type 5 (CCR5), also known as CD195, CC-CKR-5, CHEMR13, and HIV-1 fusion coreceptor. CCR5 is a 45 kDa seven-transmembrane G-protein-coupled receptor (GPCR). CCR5 is expressed on a subset of memory T cells, macrophages, and immature dendritic cells (DCs) and is upregulated by proinflammatory cytokines. CCR5 binds to inflammatory CC-chemokines, including CCL3 (macrophage inflammatory protein (MIP)-1α), CCL4 (MIP-1β), and RANTES, which increases intracellular calcium levels and results in cytoskeletal rearrangement and chemotactic cell migration. CCR5 is also the coreceptor for HIV-1 following binding of viral gp120 to CD44-7. The levels of CCR5 on cells influence the rate of entry of HIV-1, and patients with lower levels of CCR5 exhibit immunity against infection. CCR5 also contributes to other human diseases, including type I diabetes and cancer.
Concentration
≥ 5.0 mg/ml
Endotoxin
<1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity
Clone HEK/1/85a/7a recognizes an epitope on human CCR5
Purification method
This monoclonal antibody was purified using Protein G
Use
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Immunogen
CHO cells transfected with full-length human CD195 (CCR5).
Isotype Control
Rat IgG2b In Vivo Isotype Control - Low Endotoxin [1-2] (ICH2243)
Buffer
ICH3001-100ml; ICH3002-100ml; ICH3003-100ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5 mg
Available: In stock
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