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Bulk anti-Human CXCR4 (12G5) Antibody

Bulk anti-Human CXCR4 (12G5) Antibody

Item no.	ICH1199-5mg
Manufacturer	IchorBio
Amount	5 mg
Quantity options	100 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Flow Cytometry Immunohistochemistry Western Blot Immunofluorescence Immunocytochemistry Blocking Cardiovascular Research Atherosclerosis Primary Antibodies Immunochemistry Neutralization
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, FC, IF, IHC, ICC, Blocking, NT
Clone	12G5
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a
Purity	>95% by SDS-PAGE
Formula	Sterile, preservative-free, solution in PBS. BSA and Azide free.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Fusin,LESTR,CD184
Shipping Condition	Cool pack
Available
Manufacturer - Applications	Blocking, Flow Cytometry, Immunocytochemistry, Immunofluorescence Microscopy, Immunohistochemistry, Neutralization, Western Blotting
Manufacturer - Category	Low Endotoxin, anti-mouse, monoclonal antibody
Manufacturer - Targets	CXCR4
Shipping Temperature	Blue ice
Storage Conditions	This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Aggregation	Aggregation level ≤ 5%
Formulation	Sterile, preservative-free, solution in PBS. BSA and Azide free.
Antigen Distribution	CXCR4 is expressed in various organs including ovary, bone marrow, kidney, lung, small intestine, spleen, lymph nodes, brain, stomach, liver, thymus, heart, and pancreas as well as on the surface of endothelial mature and precursor cells and pericytes.
Application Notes	Each investigator should determine their own optimal working dilution for specific applications.
Background	12G5 binds specifically to both human and nonhuman cells that express recombinant CXCR4. 12G5 inhibits CD4-independent infection by some HIV-2 isolates, and preincubating cells with 12G5 abolishes syncytium formation. HIV-2/vcp-infected cells display a marked and selective reduction in 12G5 binding. 12G5 also inhibits induction of cell-to-cell fusion of CXCR4+ RD/CD4 cells by HIV-1 and HIV-2 strains.
Concentration	≥ 2.0 mg/ml
Endotoxin	<1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity	12G5 activity is directed against human CXCR4 (CD184; Fusin)
Purification method	This monoclonal antibody was purified using Protein A
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Immunogen	12G5 was produced by immunizing Balb/c mice with CP-MAC-infected Sup-T1 cells. Hybridomas were generated and screened for the ability to inhibit CP-MAC-induced syncytium induction on Sup-T1 cells.
Isotype Control	Mouse IgG2a In Vivo Isotype Control – Low Endotoxin (C1.18.4) [ICH2245]
Buffer	ICH3001-100ml, ICH3002-100ml, ICH3003-100ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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Delivery expected until 2/19/2026

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