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Theralizumab Biosimilar - Research Grade

Theralizumab Biosimilar - Research Grade

Item no.	ICH5023-100mg
Manufacturer	IchorBio
Amount	100 mg
Quantity options	100 mg 10 mg 1 mg 20 mg 50 mg 5 mg
Category	Antibodies In Vivo Antibodies
Type	Biosimilars
Applications	FA
Specific against	Human (Homo sapiens)
Isotype	IgG4
Purity	>95% by SDS-PAGE
Citations	Huang et al. A bispecific antibody AP203 targeting PD-L1 and CD137 exerts potent antitumor activity without toxicity. Journal of Translational Medicine
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	TGN1412, CD28-SuperMAB, TAB08
Shipping Condition	Cool pack
Available
Specificity	Detects human CD28. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Theralizumab.
Manufacturer - Applications	Functional Assays
Manufacturer - Category	Low endotoxin, Biosimilar, recombinant antibody
Manufacturer - Isotype	Human IgG4
Manufacturer - Targets	CD28
Shipping Temperature	Blue ice
Storage Conditions	This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
Formulation	Sterile, preservative-free, solution in PBS. BSA and Azide free.
Application Notes	This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
Background	Theralizumab GN1412 is a humanised monoclonal antibody that not only binds to, but is a strong agonist for, the CD28 receptor of the immune system’s T cells. CD28 is the co-receptor for the T cell receptor; It binds to receptors on the interacting partner in the reaction through one of its ligands (B7 family). It was withdrawn from development after inducing severe inflammatory reactions as well as chronic organ failure in the first-in-human study by PAREXEL in London in March 2006.
Concentration	5mg/ml
Endotoxin	≤ 1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity	Detects human CD28. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Theralizumab.
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Isotype Control	Bulk Human IgG4 Isotype Control (IB4) [ICH2257]
Buffer	ICH3002

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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