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Anti-Human ARMER (CT) - 0.1 mg

Anti-Human ARMER (CT) - 0.1 mg

Item no.	LEIN-A249-0.1mg
Manufacturer	Leinco Technologies
Amount	0.1 mg
Quantity options	0.1 mg 20 ug
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Stellar, H. (1995) Science 267:1445-9. 2. Nakagawa, T. et al. (2000) Nature 403:98-103. 3. Lui, HM. et al. (2003) Mol. Cancer Res. 1:508-18.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	ARMER
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA.1 Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, 2 other caspases such as caspase-9 are also thought to be activated following ER stress.3 Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, 3 although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
Background	Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA.¹ Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, ² other caspases such as caspase-9 are also thought to be activated following ER stress.³ Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, ³ although the mechanism for this remains unkown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
PubMed	ARMER
Manufacturer - Specificity	Rabbit Anti-Human ARMER recognizes an epitope near the C-terminus of human and mouse ARMER. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2828076
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:A263
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	ARMER Antibody, AIP1, ARMER, SPG61, ARL6IP, KIAA0069, ADP-ribosylation factor-like protein 6-interacting protein 1, ARL-6-interacting protein 1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-A249-0.1mg-safety-datasheet.pdf