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Anti-Human Activation-Induced Cytidine Deaminase (CT) (AID) - 0.1 mg

Anti-Human Activation-Induced Cytidine Deaminase (CT) (AID) - 0.1 mg

Item no.	LEIN-A317-0.1mg
Manufacturer	Leinco Technologies
Amount	0.1 mg
Quantity options	0.1 mg 20 ug
Category	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Primary
Applications	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Muramatsu, M. et al. (1999) J. Biol. Chem. 274:18470 2. Muramatsu, M. et al. (2000) Cell 102:553 3. Greeve, J. et al. (2003) Blood 101:3574 4. Cascalho, M. (2004) J. Immunol. 172:6513
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Room temperature
Available
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	AID
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines.1 It is necessary for somatic hypermutation and class switch recombination in B cells, 2 but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms.2, 3 Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.
Background	Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines.¹ It is necessary for somatic hypermutation and class switch recombination in B cells, ² but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms.^{2, 3} Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.
PubMed	AID
Manufacturer - Specificity	Rabbit Anti-Human Activation-Induced Cytidine Deaminase (AID) recognizes an epitope near the C-terminus of Human and Mouse AID. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2828101
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:A302
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Activation-Induced Cytidine Deaminase, AID, Human, Anti-Human Activation-Induced Cytidine Deaminase (CT) (AID), AID Antibody, AID, ARP2, CDA2, HIGM2, HEL-S-284, AID, Single-stranded DNA cytosine deaminase, Activation-induced cytidine deaminase

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-A317-0.1mg-safety-datasheet.pdf