Anti-Human BAFF-R (CT) - 20 µg

Polyclonal Antibodies>Growth Factors & Cytokines

Next Day Ambient

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4.1-4 BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion.1, 2 Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase.4

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Polyclonal Antibody, B Cell Activating Factor, TNFRSF13C, BAFF-R, BAFFR, CD268, MGC138235, BAFF-R, Human, Anti-Human BAFF-R (CT)