Anti-Human BMP-6 (Clone 74219) - 500 µg

ELISA Cap, N, WB

BMP-6

Next Day Ambient

Bone morphogenetic protein 6, also known as BMP6, is a human gene. The protein encoded by this gene is a a member of the TGFβ superfamily. Bone morphogenetic proteins are known for their ability to induce the growth of bone and cartilage. BMP6 is able to induce all osteogenic markers in mesenchymal stem cells. The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity.

Neutralization: This antibody is useful for neutralization of Human BMP-6 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human BMP-6 (at 150 ng/ml) is 0.5 - 2 µg/ml.

Mouse Anti-Human Bone Morphogenetic Protein 6 (BMP-6) (Clone 74219) recognizes an epitope on Human BMP-6. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 6.4 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Purified Recombinant Human BMP-6 (Accession # Q4VBA3)

Monoclonal Antibody, Bone Morphogenetic Protein 6, VGR, VGR1, 74219, BMP-6, Human, Anti-Human BMP-6, BMP6, BMP-6, bone morphogenetic protein 6, vegetal related growth factor (TGFB-related), vegetal-related (TGFB related) cytokine, VG-1-R, VG-1-related protein, Vg1-related sequence, VGR, VGR1, Vgr-1