Anti-Mouse CD25 - Purified <i>in vivo </i>GOLD™ Functional Grade - 1.0 mg

B, Depletion, FA, FC, IHC FF, in vivo, IP, PhenoCycler®, WB

CD25

Next Day 2 - 8°C

CD25, a 55 kD type I transmembrane glycoprotein, has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Many resting memory T cells constitutively express IL2RA. It functions as the receptor for HTLV-1, resulting in its expression on neoplastic cells in adult T cell lymphoma/leukemia. CD25 (sIL-2R) has been used to track disease progression. Some additional clinical applications include Chagas disease, a disease characterized by a decline of CD25 expression on immune cells, and Multiple sclerosis, in which treatments with mAbs target CD25.

Forms high affinity IL-2R with IL-2Rβ (CD122) and IL-2Rγ (CD132)

CD25

Immunology

AB_2737451

This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

CD25 is expressed in activated T cells and B cells, thymocyte subset, pre-B cells, T regulatory cells.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.